DOES THE TRAINED IMMUNE SYSTEM PLAY AN IMPORTANT ROLE IN THE EXTREME LONGEVITY THAT IS SEEN IN THE SARDINIAN BLUE ZONE?

Does the trained immune system play an important role in the extreme longevity that is seen in the Sardinian blue zone?

Villages in the ACTA-RESVERATROL island of Sardinia in the Mediterranean that display exceptional longevity are clustered within a defined mountainous region.Because of their unique location we hypothesize that these villages had a unique infectious disease exposure relevant to the observed successful longevity.These highland villages had a signifi

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A pilot evaluation of an online cognitive behavioral therapy for insomnia disorder – targeted screening and interactive Web design lead to improved sleep in a community population

Kirstie N Anderson, Paul Goldsmith, Alison Gardiner Regional Sleep Service, Freeman Hospital, Newcastle upon Tyne, UK Introduction: Computerized or online cognitive behavioral therapies (CBTs) are increasingly being developed to deliver insomnia therapy (CBT-i).They seek to address the difficulty of delivering an evidence-based technology to a larg

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Analysis of Screen Generic Lightlike Submanifolds in an Indefinite Kaehler Statistical Manifold Endowed with a Quarter-Symmetric Non-Metric Connection

This paper introduces the notion of screen SENIOR PROBIOTIC generic lightlike submanifolds (SGLSs) of an indefinite Kaehler statistical manifold equipped with a quarter-symmetric non-metric (QSNM) connection, supported by suitable illustrations.Assertions for induced connection on the lightlike submanifold and integrability of the distributions are

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